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Stress the importance of clear protocols for stopping or adjusting GLP-1 therapy before surgery

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In vitro, 16-hour incubation of mouse primary pituitary cultures with CJC-1295 DAC produced a concentration-dependent increase in GH in the medium, and at 10 ng/mL caused DNA damage on comet assay together with increased H2AX expression, a marker of the double-strand-break response